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2. A Ral Guanine Exchange Factor-Ral Pathway Is Conserved in ... - NCBI
Adult compound eyes from GMR-Gal4/+ (A and D), GMR-Gal4/+ UAS-Rgl1-CAAX ... When searching for genetic interactions between Ras1 and Ral, we found that ...
Ras GTPases are central to many physiological and pathological signaling pathways and act via a combination of effectors. In mammals, at least three Ral exchange factors (RalGEFs) contain a Ras association domain and constitute a discrete subgroup of ...
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8. The Ral/Exocyst Effector Complex Counters c-Jun N-Terminal Kinase ...
... adult stage. Similarly, PG69 males were rescued by the removal of one copy ... search the molecular avatar(s) of this activity. In a two-hybrid screen ...
Ral GTPase activity is a crucial cell-autonomous factor supporting tumor initiation and progression. To decipher pathways impacted by Ral, we have generated null and hypomorph alleles of the Drosophila melanogaster Ral gene. Ral null animals were not ...
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10. RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and ...
Jun 7, 2021 · Search · Alerts · Submit your research ... RAL GTPases become essential mediators of adult tissue homeostasis and malignant transformation.
Combined genetic experiments and cellular trafficking assays in Drosophila and mammalian models uncover a new role of RAS-like GTPases in EGFR signalling activation during tissue regeneration and tumourigenesis through regulation of EGFR internalisation.
